CAS 100929-99-5

phe-arg B-naphthylamide dihydrochloride

Description:

Phe-Arg B-naphthylamide dihydrochloride, identified by its CAS number 100929-99-5, is a synthetic compound often utilized in biochemical research, particularly in studies involving proteases and enzyme activity. This substance is characterized by its structure, which includes a phenylalanine (Phe) and arginine (Arg) moiety linked to a B-naphthylamide group, contributing to its specificity and interaction with biological targets. As a dihydrochloride salt, it is typically more soluble in aqueous solutions, facilitating its use in various experimental conditions. The compound is known for its role as a substrate or inhibitor in enzymatic assays, making it valuable in the exploration of proteolytic pathways. Its properties, such as melting point, solubility, and stability, can vary based on environmental conditions and the presence of other reagents. Safety data should be consulted to ensure proper handling, as with any chemical substance, to mitigate risks associated with exposure.

Formula: C₂₅H₃₀N₆O₂.2HCl

InChI: InChI=1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H

InChI key: ZMTAZQYLEGNUTJ-UHFFFAOYSA-N

SMILES: C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC2=CC3=CC=CC=C3C=C2)N.Cl

Synonyms:

• H-Phe-Arg-.beta.NA . 2 HCl
• Phe-Arg Beta-Naphthylamide Dihydrochloride

H-Phe-Arg-βNA · 2 HCl

CAS: 100929-99-5

Substrate for dipeptidyl aminopeptidase I (cathepsin C). A broad-spectrum efflux pump inhibitor in gram-negative bacteria. PAbN has been evaluated as an adjunct to antibiotics, as efflux in bacteria mediates antibiotic resistance. Vecchione et al. demonstrated that Phe-Arg-β-naphthylamide could potentiate drug activity also against a gram-positive bacterium. PAbN permeabilizes the outer membrane of gram-negative bacteria (Lamers et al.).

Formula: C₂₅H₃₀N₆O₂·2HCl

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 519.47

Ref: 01-4000885

PAβN dihydrochloride

CAS: 100929-99-5

PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.

Formula: C₂₅H₃₂Cl₂N₆O₂

Purity: 99.82% - >99.99%

Color and Shape: White Solid

Molecular weight: 519.467

Ref: TM-T12374

PAβN dihydrochloride

CAS: 100929-99-5

PAβN dihydrochloride

Formula: C₂₅H₃₂Cl₂N₆O₂

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 519.47

Ref: 54-BUP10856

Phe-Arg b-naphthylamide dihydrochloride

CAS: 100929-99-5

Formula: C₂₅H₃₀N₆O₂·2HCl

Purity: ≥ 98%

Color and Shape: White or off-white powder

Molecular weight: 519.47

Ref: 7W-GE7650

(S)-2-((S)-2-Amino-3-Phenylpropanamido)-5-Guanidino-N-(Naphthalen-2-yl)Pentanamide Dihydrochloride

CAS: 100929-99-5

Formula: C₂₅H₃₂Cl₂N₆O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 519.4666

Ref: IN-DA00913K

Phe-Arg-b-naphthylamide Dihydrochloride

Controlled Product

CAS: 100929-99-5

Applications Phe-Arg-beta-naphthylamide Dihydrochloride can be used as a reagent in organic synthesis.
References Low, May L., et al.: Bioconjugate Chem., 25(12), 2269-2284 (2014)

Formula: C₂₅H₃₂Cl₂N₆O₂

Color and Shape: Neat

Molecular weight: 519.47

Ref: TR-P998425

PAβN 2HCl

CAS: 100929-99-5

(S)-2-((S)-2-Amino-3-phenylpropanamido)-5-guanidino-N-(naphthalen-2-yl)pentanamide dihydrochloride

Formula: C₂₅H₃₂Cl₂N₆O₂

Purity: 99%

Molecular weight: 519.47

Ref: IN-DG147374

Phe-Arg-β-NA·2HCl

CAS: 100929-99-5

Phe-Arg-beta-NA·2HCl is a drug that acts as an inhibitor of the bacterial efflux pump. It binds to the bacterial outer membrane and blocks the active transport of a wide variety of antibiotics, including ciprofloxacin and flumequine. Phe-Arg-beta-NA·2HCl has been shown to inhibit efflux mediated by many different efflux pumps, including RND, MFS, and ABC transporters. This drug also inhibits the growth of bacteria from the genera Pseudomonas, Stenotrophomonas, Serratia, Acinetobacter, and Enterobacteriaceae.

Formula: C₂₅H₃₀N₆O₂•(HCl)₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 519.47 g/mol

Ref: 3D-FP49339

(S)-2-((S)-2-Amino-3-phenylpropanamido)-5-guanidino-N-(naphthalen-2-yl)pentanamide dihydrochloride

CAS: 100929-99-5

Purity: 99%

Molecular weight: 519.4699707

Ref: 10-F869006