01-D-2495 - h-cys4-methoxytrityl-2-chlorotrityl-resin-200-400-mesh-04-07-mmolg

<p>It is used as selective protecting reagent that is used for primary hydroxyl groups. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item </p>

<p>It is used as an intermediate for preparation of TT-0011. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has n</p>

4-Methoxytrityl (Mmt) is a very acid-sensitive cysteine protecting group that can selectively be removed by 0.5-1.0% TFA in the presence of scavengers, e.g. TES. Protecting groups of the t-butyl type and S-Trt are left intact under these conditions. Cleavage and cyclization can be achieved concomitantly by adding iodine. It can be used in the solid-phase synthesis of cysteine-containing peptides, and further to selectively deprotect a thiol function in order to introduce a labeling group. Rijkers et al. employed p-methoxytrityl protection for obtaining S-palmitoylated peptides on-resin. The high acid lability of Cys(Mmt) was exploited by Roberts et al. to obtain a library of thioether-linked cyclic peptides. Arendt et al. employed Cys(Mmt) for the synthesis of peptides containing cysteic acid by selective deblocking and oxidation of the thiol moiety with performic acid. Mmt is fully stable to HOBt.

4-Methoxytrityl (Mmt) is a very acid sensitive cysteine protecting group that can selectively be removed by 0.5 – 1.0% TFA in the presence of protecting groups of the t-butyl type and S-Trt. It can be used in the solid-phase synthesis of cysteine-containing peptides, and further to selectively protect a thiol function in order to introduce a labeling group.

Fmoc-Lys(Mmt) is a versatile tool for the synthesis of sensitive drugs, due to the easy removal of the 4-methoxytrityl protecting group under mild conditions by reagents such as dichloroacetic acid or chloroacetic acid in CH₂Cl₂ / anisole.

<p>Bachem ID: 4028399.</p>

Active ester of Fmoc-Lys(Mmt). Mmt can be cleaved selectively.

<p>3'-beta-Azido-2',3'-dideoxy-5'-O-(4-methoxytrityl)uridine is a Nucleoside Derivative - 2',3'-Dideoxy nucleoside, 3'-Modified nucleoside, Azido-nucleoside, Xylo-</p>

<p>Nucleoside Derivatives - Xylo-nucleosides, 2’-Deoxy-nucleosides; ; Protected nucleosides with NH2/OH group</p>

<p>3'-b-Amino-2',3'-dideoxy-5'-O-methoxytrityl-5-methyluridine is a Nucleoside Derivative - Amino-nucleoside, Xylo-nucleoside, 2',3'-Didexoy nucleoside, 3'-</p>

<p>Methoxytrityl-N-PEG4-acid</p>