Berberine chloride

CAS: 633-65-8

Ref. 02-J62311

Product Information

• Name: Berberine chloride
• Synonyms: berberine chloride, 1,3-Benzodioxolo[5,6-A]Benzo[G]Quinolizinium, 5,6-Dihydro-9,10-Dimethoxy-, Hydrochloride (1:1), 16,17-Dimethoxy-5,7-dioxa-13λ5-azapentacyclo[11.8.0.0[2,10].0[4,8].0[15,20]]henicosa-1(21),2(10),3,8,13,15(20),16,18-octaen-13-ylium chloride, Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride, Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride (1:1), Berberberberine hydrochloride n-hydrate, Berberine IR, Berberine hcl, Berberinium chloride, Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, chloride, NSC 163088, NSC 646666, ine HCl
• CAS: 633-65-8

Description

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

• Brand: Alfa Aesar By Thermo Fisher Scientific

Chemical properties

• Molecular weight: 371.82
• Formula: C₂₀H₁₈ClNO₄
• Color/Form: Yellow to orange, Powder
• InChI key: VKJGBAJNNALVAV-UHFFFAOYSA-M