10-312022 - 5-iodo-1-methyl-1h-tetrazole | 33452-18-5

<p>Tetrazole</p>

<p>Tetrazole (1H-TETRAZOLE) is the bioisoster of carboxylic acid, possess considerable antibacterial property.</p>

<p>Glycogen phosphorylase inhibitor</p>

<p>Tetrazole blue is a tetrazole compound that is used as a reagent for the determination of certain metals in water and other polar solvents. It has been used as a building block in synthesis, and is also an intermediate for the production of other compounds. Tetrazole blue is soluble in organic solvents such as acetone, ethyl acetate, chloroform, and ethanol. This compound can be stored at room temperature but should be kept away from air and moisture. Tetrazole blue has a CAS number of 7703-11-9.</p>

<p>Applications 5-Methyl Tetrazole is used in the preparation of novel antifungal agents based derived from N-iodopropargylazoles and N-triiodoallylazoles. 5-Methyl Tetrazole also in the preparation of novel quinoline derivatives against mycobacterium tuberculosis.<br>References Koyama, M. et al.: J. Med. Chem., 30, 552 (1987); Upadhayaya, R. et al.: Bioorg. Med. Chem., 17, 2830 (2009);<br></p>

<p>5-(4-Hydroxyphenyl) tetrazole is a hydrophobic ligand that has been shown to bind to cisplatin and therefore may have potential use in cancer therapy. It has also been used as an anti-inflammatory agent with the potential to inhibit prostaglandin synthesis. 5-(4-Hydroxyphenyl) tetrazole binds to hydrogen peroxide, which is a strong oxidizing agent and produces reactive oxygen species (ROS). ROS can cause DNA damage and lead to cell death by apoptosis or necrosis. 5-(4-Hydroxyphenyl) tetrazole reacts with cisplatin, which is a chemotherapeutic agent that is used in the treatment of various types of cancer. Cisplatin binds to DNA and prevents replication, leading to cell death. Hydrophobic ligands such as 5-(4-Hydroxyphenyl) tetrazole are able to bind more tightly than other ligands because</p>