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Clofazimine
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Clofazimine

CAS: 2030-63-9

Ref. 3D-AC20496

2g
87.00 €
5g
161.00 €
10g
232.00 €
25g
435.00 €
50g
532.00 €
Estimated delivery in United States, on Wednesday 2 Oct 2024

Product Information

Name:
Clofazimine
Controlled Product
Synonyms:
  • N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazina mine3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2- (isopropylimino)phenazine
  • (3E)-N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
  • 2-(4-Chloroanilino)-3-isopropylimino-5-(4-chlorophenyl)-3,5-dihydrophenazine
  • 2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-
  • 2-p-Chloroanilino-5-p-chlorophenyl-3,5-dihydro-3-isopropyliminophenazine
  • 3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)phenazine
  • 4-chloro-N-(5-(4-chlorophenyl)-3,5-dihydro-3-isopropyliminophenazin-2-yl)aniline
  • B 663
  • B 663 (pharmaceutical)
  • Chlofazimine
  • See more synonyms
  • Clofacimira
  • Clofazimin
  • G 30320
  • Hansepran
  • Lampren
  • Lamprene
  • N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine
  • Nsc 141046
  • Phenazine, 3-(p-chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-
Description:

Clofazimine is an anti-tuberculosis drug that belongs to the class of phenazine antibiotics. It is used in the treatment of lymphoma patients, as well as in the prevention and treatment of tuberculosis. Clofazimine inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Clofazimine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
473.4 g/mol
Formula:
C27H22Cl2N4
Purity:
Min. 95%
Color/Form:
Powder
InChI:
InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24-
InChI key:
InChIKey=WDQPAMHFFCXSNU-KRUMMXJUSA-N
SMILES:
CC(C)/N=c1/cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1
MDL:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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