Validamycin A

CAS: 37248-47-8

Ref. 3D-AV59477

Product Information

• Name: Validamycin A
• Synonyms: ((1S,4R,5S,6S)-4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-, (1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexyl beta-D-glucopyranoside, (1S,2S,3R,4R,6S)-2,3-dihydroxy-6-(hydroxymethyl)-4-{[(4S,5R,6R)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexyl beta-D-glucopyranoside, (1S-(1a,4a,5B,6a))-1,5,6-Trideoxy-3-O-B-D-glucopyranosyl-5-, (1S-(1alpha,4alpha,5beta,6alpha))-1,5,6-trideoxy-4-O-beta-D-, (hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-, (hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiro-inositol, 1,5,6-Trideoxy-4-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-<smallcap>D</span>-chiro-inositol, 1L-(1,3,4/2,6)-2,3-Dihydroxy-6-hydromethyl-4-((1S,4R,5S,6S)-, 1L-(1,3,4/2,6)-2,3-Dihydroxy-6-hydroxymethyl-4-, 2,3-Dihydroxy-6-(Hydroxymethyl)-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Cyclohexyl Hexopyranoside, 4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-, <span class="text-smallcaps">D</smallcap>-chiro-Inositol, 1,5,6-trideoxy-4-O-β-<smallcap>D</span>-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-, <span class="text-smallcaps">D</smallcap>-chiro-Inositol, 1,5,6-trideoxy-4-O-β-<smallcap>D</span>-glucopyranosyl-5-(hydroxymethyl)-1-[[4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-, [1S-(1α,4α,5β,6α)]-, Cepex 10SL, D-1,5,6-Trideoxy-3-O-beta-D-glucopyranosyl-5-, Jinganmycin A, Jinggang, Jinggangmycin, Jinggangmycin A, Validacin, Validamycin, cyclohexen-1-yl)amino)-D-chiroinositol, cyclohexen-1-yl)amino)-d-chiro-inositol, enylamino)cyclohexyl beta-D-glucopyranoside, glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-, D-chiro-Inositol, 1,5,6-trideoxy-4-O-β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-, [1S-(1α,4α,5β,6α)]-, 1,5,6-Trideoxy-4-O-β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol, D-chiro-Inositol, 1,5,6-trideoxy-4-O-β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-

Description

Validamycin A is a natural product that has significant cytotoxicity against wild-type strains of the bacterium Pseudomonas aeruginosa. It also has an inhibitory effect on human macrophages and detoxification enzymes, such as glutathione reductase and cytochrome P450. Validamycin A binds to cell nuclei and can be detected at low concentrations. The synergic effects of this compound with chemical pesticides have been shown to be effective in the bacterial strain Pseudomonas putida. Validamycin A is broken down by the enzyme carbonate dehydratase and sodium carbonate, which are found in plants or animals.

• Brand: Biosynth

Chemical properties

• Molecular weight: 497.49 g/mol
• Formula: C₂₀H₃₅NO₁₃
• Purity: Min. 92 Area-%
• Color/Form: White Powder