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Afatinib dimaleate
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Afatinib dimaleate

CAS: 850140-73-7

Ref. 3D-BA162012

1g
3,706.00 €
10mg
172.00 €
50mg
453.00 €
200mg
1,159.00 €
500mg
2,319.00 €
Estimated delivery in United States, on Thursday 16 Jan 2025

Product Information

Name:
Afatinib dimaleate
Synonyms:
  • 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:2)
  • BIBW2992 DiMaleate
  • Bibw 2992Ma2
  • Bibw2992-Ma2
Description:

Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
718.08 g/mol
Formula:
C24H25ClFN5O3·C8H8O8
Purity:
Min. 95%
Color/Form:
Solid
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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