Product Information
Name:A 196
Synonyms:
- 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamineA196
Brand:Biosynth
Description:Selective inhibitor histone methyltransferases SUV420H1 and SUV420H2 (IC50 values = 25 nM and 144 nM, respectively). Reduces histone H4K20me2 and H4K20me3 expression whilst increasing H4K20me1 global expression. Inhibits formation of p53-binding protein 1 (53BP1) foci upon ionizing radiation and reduces NHEJ-mediated DNA-break repair.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:359.25 g/mol
Formula:C18H16Cl2N4
Purity:Min. 95%
Color/Form:Solid
InChI:InChI=1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)
InChI key:InChIKey=ABGOSOMRWSYAOB-UHFFFAOYSA-N
SMILES:Clc1cc2c(NC3CCCC3)nnc(-c3ccncc3)c2cc1Cl
Technical inquiry about: A 196
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