A 196

CAS: 1982372-88-2

Ref. 3D-BA164085

Product Information

• Name: A 196
• Synonyms: 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamineA196
• Brand: Biosynth
• Description: Selective inhibitor histone methyltransferases SUV420H1 and SUV420H2 (IC50 values = 25 nM and 144 nM, respectively). Reduces histone H4K20me2 and H4K20me3 expression whilst increasing H4K20me1 global expression. Inhibits formation of p53-binding protein 1 (53BP1) foci upon ionizing radiation and reduces NHEJ-mediated DNA-break repair.

Chemical properties

• Molecular weight: 359.25 g/mol
• Formula: C₁₈H₁₆Cl₂N₄
• Purity: Min. 95%
• Color/Form: Solid
• InChI: InChI=1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)
• InChI key: InChIKey=ABGOSOMRWSYAOB-UHFFFAOYSA-N
• SMILES: Clc1cc2c(NC3CCCC3)nnc(-c3ccncc3)c2cc1Cl