Estimated delivery in United States, on Tuesday 21 Jan 2025
Product Information
Name:
BIO
Synonyms:
- (2'Z,3'E)-6-Bromoindirubin-3'-oxime
- (3Z)-6-Bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
- (2′Z,3′E)-6-Bromoindirubin-3′-oxime
- 2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-
- GSK 3 IX
- GSK 3 Inhibitor IX
Description:
Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
356.17 g/mol
Formula:
C16H10BrN3O2
Purity:
Min. 95%
Color/Form:
Red To Dark Red Solid
InChI:
InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H
InChI key:
InChIKey=SAQUSDSPQYQNBG-UHFFFAOYSA-N
SMILES:
O=Nc1c(-c2c(O)[nH]c3cc(Br)ccc23)[nH]c2ccccc12
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:
Technical inquiry about: 3D-BB162775 BIO
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