Cladribine - Bio-X ™

CAS: 4291-63-8

Ref. 3D-BC164318

Product Information

• Name: Cladribine - Bio-X ™
• Synonyms: Leustatin9-(2-Deoxy-b-D-ribofuranosyl)-2-chloroadenine, (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol, 2-CdA, 2-Chloro-2'-deoxy-β-adenosine, 2-Chloro-2'-deoxyadenosine, 2-Chloro-6-amino-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)purine, 2-Chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine, 2-Chlorodeoxyadenosine, Biodribin, Cladarabine, Cladribine, CldAdo, Jk 6251, Leustat, Leustatin, Litak, Mavenclad, Nsc 105014, Nsc 105014-F, Rwj 26251, Vero-Cladribine, Adenosine, 2-chloro-2′-deoxy-

Description

Cladribine is a purine nucleoside analogue that interferes with DNA synthesis by acting as a false building block in the DNA chain during replication. Cladribine is incorporated into the growing DNA chain, causing chain termination and leading to DNA damage, apoptosis (programmed cell death), and ultimately cell death. Cladribine is structurally similar to adenosine, but is partially resistant to breakdown by adenosine deaminase due to a chlorine molecule at position 2. This causes it to accumulate in cells and interfere with the targeted cell's ability to process DNA. This mechanism of action makes cladribine an effective treatment for certain types of cancer and autoimmune diseases, where it targets rapidly dividing cells.

Cladribine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

• Brand: Biosynth

Chemical properties

• Molecular weight: 285.69 g/mol
• Formula: C₁₀H₁₂ClN₅O₃
• Purity: Min. 97 Area-%
• Color/Form: Powder