GSK 583

CAS: 1346547-00-9

Ref. 3D-BG163813

Product Information

• Name: GSK 583
• Synonyms: 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
• Brand: Biosynth
• Description: A potent and selective inhibitor of cell death-inducing kinase RIP2 (IC50 = 5 nM). Reduces release of pro-inflammatory cytokines. Inhibits production of TNF-α and IL-6 in intestinal explants from patients with Crohn's disease and ulcerative colitis.

Chemical properties

• Molecular weight: 398.46 g/mol
• Formula: C₂₀H₁₉FN₄O₂S
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
• InChI key: InChIKey=XLOGLWKOHPIJLV-UHFFFAOYSA-N
• SMILES: CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1