Gemcitabine hydrochloride - Bio-X ™

CAS: 122111-03-9

Ref. 3D-BG164501

Product Information

• Name: Gemcitabine hydrochloride - Bio-X ™
• Synonyms: 2'-Deoxy-2',2'-difluorocytidine hydrochloride
• Brand: Biosynth

Description

Gemcitabine is as a synthetic pyrimidine nucleoside prodrug. The hydrogen atoms on the 2' carbon of deoxycytidine are replaced by fluorine atoms. Gemcitabine works by being incorporated into the DNA of cancer cells during replication and inhibiting DNA synthesis. First gemcitabine is converted into its active form, gemcitabine triphosphate, by cellular enzymes including deoxycytidine kinase (DCK), after it is taken up by cancer cells. The gemcitabine triphosphate interferes with the normal functioning of the enzymes involved in replicating DNA, leading to the termination of DNA synthesis and ultimately, cell death. Gemcitabine is used as a chemotherapy drug used to treat various types of cancer, including pancreatic, lung, breast, and ovarian cancer.

Chemical properties

• Molecular weight: 299.66 g/mol
• Formula: C₉H₁₁F₂N₃O₄•HCl
• Purity: Min. 98 Area-%
• Color/Form: Powder