GSK 1278863

CAS: 960539-70-2

Ref. 3D-BG166670

Product Information

• Name: GSK 1278863
• Synonyms: DaprodustatN-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]glycine
• Brand: Biosynth
• Description: Inhibitor of HIF-prolyl hydroxylase isozymes PHD1, PHD2 and PHD3 with Ki in nanomolar range. The compound mimics the binding of N-oxalylglycine, chelates catalytic iron and prevents substrate entry into catalytic site. Inhibition of PHD enzymes leads to stabilization of hypoxia-induced factors HIF1α and HIF2α, followed by the production of erythropoietin (EPO).

Chemical properties

• Molecular weight: 393.43 g/mol
• Formula: C₁₉H₂₇N₃O₆
• Purity: (%) Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)
• InChI key: InChIKey=RUEYEZADQJCKGV-UHFFFAOYSA-N
• SMILES: O=C(O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O