LSN 3154567
CAS:
Ref. 3D-BL165041
10mg
295.00€
25mg
517.00€
50mg
820.00€
100mg
1,389.00€
250mg
3,078.00€
Product Information
Name:LSN 3154567
Synonyms:
- 2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide
Brand:Biosynth
Description:Nicotinamide phosphoribosyl transferase (NAMPT) competitive inhibitor with IC50 = 3.1 nM. A major consequence of NAMPT inhibition is the attenuation of glycolysis at the GADPH step because this enzyme requires NAD+ for activity. The compound exhibits broad spectrum anti-cancer activity and significant tumor regression was observed in vitro. Although retinal and haematological toxicity has been associated with NAMPT inhibitors, LSN 3154567 does not lead to retinopathy in rats and can be mitigated with co-administration of nicotinic acid.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:419.5 g/mol
Formula:C20H25N3O5S
Purity:Min. 95%
Color/Form:Powder
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