ML188
CAS: 1417700-13-0
Ref. 3D-BM178806
| 5mg | 1,216.00 € | ||
| 10mg | 1,540.00 € | ||
| 25mg | 2,269.00 € | ||
| 50mg | 2,755.00 € | ||
| 100mg | 4,211.00 € |
Product Information
ML188 is a covalent inhibitor of the mammalian target of rapamycin (mTOR). It was originally developed as an anti-cancer drug, but has also shown efficacy in treating autoimmune diseases and bowel disease. ML188 binds to the ATP-binding site of mTOR, which prevents the formation of complex 1, leading to its inhibition. This binding leads to a decrease in proinflammatory cytokines and chemokines such as TNFα, IL-6, and IL-12. The binding of ML188 is reversible, with dissociation constants in the low nanomolar range. The binding of ML188 leads to decreased expression levels for cyclin D1, c-Myc, p21 and p27 proteins. ML188 also inhibits growth factor activity by preventing phosphorylation of Akt/PI3K. In addition to inhibiting mTOR activity, ML188 may inhibit protein synthesis by interfering with ribosomal function.
ML188 has been shown to be effective
Chemical properties
Technical inquiry about: 3D-BM178806 ML188
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