O151

CAS: 304478-23-7

Ref. 3D-BO168359

Product Information

• Name: O151
• Synonyms: 2-Cyclohexylidenehydrazide-4-bromobenzoic acid

Description

Selective and potent inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.6 μM. OGG1 is a key enzyme in DNA repair mechanism called base excision repair (BER). The compound inhibits the hydrolysis of glycosidic bond required for the excision of 8-oxoguanine from double stranded DNA, which leads to accumulation of mutations. It has been proposed as monotherapy for certain types of cancers as well as adjuvant for cancer therapy with DNA damaging agents. It has potential to sensitize tumours for chemotherapy and inhibit development of drug resistance mechanisms.

• Brand: Biosynth

Chemical properties

• Molecular weight: 295.18 g/mol
• Formula: C₁₃H₁₅BrN₂O
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C13H15BrN2O/c14-11-8-6-10(7-9-11)13(17)16-15-12-4-2-1-3-5-12/h6-9H,1-5H2,(H,16,17)
• InChI key: InChIKey=MYANQCMUOIPHBP-UHFFFAOYSA-N
• SMILES: O=C(NN=C1CCCCC1)c1ccc(Br)cc1