Product Information
Name:O151
Synonyms:
- 2-Cyclohexylidenehydrazide-4-bromobenzoic acid
Brand:Biosynth
Description:Selective and potent inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.6 μM. OGG1 is a key enzyme in DNA repair mechanism called base excision repair (BER). The compound inhibits the hydrolysis of glycosidic bond required for the excision of 8-oxoguanine from double stranded DNA, which leads to accumulation of mutations. It has been proposed as monotherapy for certain types of cancers as well as adjuvant for cancer therapy with DNA damaging agents. It has potential to sensitize tumours for chemotherapy and inhibit development of drug resistance mechanisms.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:295.18 g/mol
Formula:C13H15BrN2O
Purity:Min. 95%
Color/Form:Powder
InChI:InChI=1S/C13H15BrN2O/c14-11-8-6-10(7-9-11)13(17)16-15-12-4-2-1-3-5-12/h6-9H,1-5H2,(H,16,17)
InChI key:InChIKey=MYANQCMUOIPHBP-UHFFFAOYSA-N
SMILES:O=C(NN=C1CCCCC1)c1ccc(Br)cc1
Technical inquiry about: O151
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