Estimated delivery in United States, on Tuesday 17 Dec 2024
Product Information
Name:
PNU 120596
Synonyms:
- N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)urea
- 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea
- N-(5-Chloro-2,4-Dimethoxyphenyl)-N'-(5-Methyl-3-Isoxazolyl)-Urea
- NSC 216666
- Pnu 120596
- Urea, N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-
- 1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea
Description:
A type-II positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors with IC50 values of 216 nM. Increases calcium flux in response to agonists, by lengthening the channel’s mean open time. Ex vivo and in vivo models of ischemic stroke demonstrate the conversion of endogenous choline or acetylcholine into neuroprotective agents by PNU 120596.
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
311.72 g/mol
Formula:
C13H14ClN3O4
Purity:
Min. 95%
Color/Form:
Powder
InChI:
InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
InChI key:
InChIKey=CEIIEALEIHQDBX-UHFFFAOYSA-N
SMILES:
COc1cc(OC)c(NC(=O)Nc2cc(C)on2)cc1Cl
MDL:
Melting point:
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Density:
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EINECS:
Merck:
HS code:
Technical inquiry about: 3D-BP162686 PNU 120596
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