Product Information
Name:PNU 120596
Synonyms:
- N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)urea
Brand:Biosynth
Description:A type-II positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors with IC50 values of 216 nM. Increases calcium flux in response to agonists, by lengthening the channel’s mean open time. Ex vivo and in vivo models of ischemic stroke demonstrate the conversion of endogenous choline or acetylcholine into neuroprotective agents by PNU 120596.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:311.72 g/mol
Formula:C13H14ClN3O4
Purity:Min. 95%
Color/Form:Powder
InChI:InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
InChI key:InChIKey=CEIIEALEIHQDBX-UHFFFAOYSA-N
SMILES:COc1cc(OC)c(NC(=O)Nc2cc(C)on2)cc1Cl
Technical inquiry about: PNU 120596
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