Product Information
Name:PF 9366
Synonyms:
- 7-Chloro-N,N-dimethyl-5-phenyl[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine
Brand:Biosynth
Description:An allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform, with an IC50 value of 420nM. Binding of PF9366 to Mat2A overlaps with the binding site of Mat2B, a regulator of Mat2A. Mat2A inhibition in cells by PF 9366 reduces synthesis of S-adenosylmethionine (SAM).
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:350.84 g/mol
Formula:C20H19ClN4
Purity:Min. 95%
Color/Form:Solid
InChI:InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3
InChI key:InChIKey=LYLASWLQCMKZAT-UHFFFAOYSA-N
SMILES:CN(C)CCc1nnc2cc(-c3ccccc3)c3cc(Cl)ccc3n12
Technical inquiry about: PF 9366
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