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Pomalidomide - Bio-X ™
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Pomalidomide - Bio-X ™

CAS: 19171-19-8

Ref. 3D-BP164278

10mg
136.00 €
Estimated delivery in United States, on Thursday 19 Dec 2024

Product Information

Name:
Pomalidomide - Bio-X ™
Synonyms:
  • 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
  • 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
  • 2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione
  • 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
  • 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
  • 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • 4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
  • 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
  • See more synonyms
  • Actimid
  • Cc 4047
  • Imnovid
  • Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-
  • Pomalyst
Description:

Pomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.
Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
273.24 g/mol
Formula:
C13H11N3O4
Purity:
Min. 99 Area-%
Color/Form:
Powder
InChI:
InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI key:
InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N
SMILES:
Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
MDL:
Melting point:
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EINECS:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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