Sitravatinib

CAS: 1123837-84-2

Ref. 3D-BS166446

Product Information

• Name: Sitravatinib
• Synonyms: MGCD516
• Brand: Biosynth
• Description: Inhibits multiple receptor tyrosine kinases (RTKs), including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl. Sitravatinib inhibits proliferation of sarcoma cells and reduced tumor growth in vivo. Promotes immune response in tumor microenvironment and enhances sensitivity to immune checkpoint inhibitors. This compound is undergoing several clinical trials as a potential anti-cancer therapeutic agent.

Chemical properties

• Molecular weight: 629.68 g/mol
• Formula: C₃₃H₂₉F₂N₅O₄S
• Purity: Min. 95%
• Color/Form: Solid
• InChI: InChI=1S/C33H29F2N5O4S/c1-43-15-14-36-18-20-2-8-25(38-19-20)29-17-26-30(45-29)28(10-13-37-26)44-27-9-7-23(16-24(27)35)40-32(42)33(11-12-33)31(41)39-22-5-3-21(34)4-6-22/h2-10,13,16-17,19,36H,11-12,14-15,18H2,1H3,(H,39,41)(H,40,42)
• InChI key: InChIKey=WLAVZAAODLTUSW-UHFFFAOYSA-N
• SMILES: COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1