Product Information
- 4- (4- Bromo- 2
- 3- dihydro- 2- oxo- 1H- benzimidazol- 1- yl) - N- (4- iodophenyl) -1- piperidinecarboxamid eTH5487
Specific inhibitor of 8-oxoguanine glycosylase OGG1 with IC50 in submicromolar range. The compound inhibits binding of OGG1 to its substrate 8-oxoguanine, a guanine analog generated in the presence of reactive oxygen species (ROS). It was shown that TH5487 decreases inflammation level by inhibiting the base excision DNA repair in mice and altering the OGG1 chromatin dynamics. The compound also has implications in cancer biology since OGG1 inhibitors sensitise tumours to chemotherapy.
Chemical properties
Technical inquiry about: 3D-BT168024 TH 5487
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