Product Information
Name:TH 5487
Synonyms:
- 4- (4- Bromo- 2
- 3- dihydro- 2- oxo- 1H- benzimidazol- 1- yl) - N- (4- iodophenyl) -1- piperidinecarboxamid eTH5487
Brand:Biosynth
Description:Specific inhibitor of 8-oxoguanine glycosylase OGG1 with IC50 in submicromolar range. The compound inhibits binding of OGG1 to its substrate 8-oxoguanine, a guanine analog generated in the presence of reactive oxygen species (ROS). It was shown that TH5487 decreases inflammation level by inhibiting the base excision DNA repair in mice and altering the OGG1 chromatin dynamics. The compound also has implications in cancer biology since OGG1 inhibitors sensitise tumours to chemotherapy.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:541.18 g/mol
Formula:C19BrH18IN4O2
Purity:Min. 95%
Color/Form:Solid
Technical inquiry about: TH 5487
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