WM 8014

CAS: 2055397-18-5

Ref. 3D-BW166844

Product Information

• Name: WM 8014
• Synonyms: MOZ-IN-3

Description

Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values of 8 nM and 28 nM, respectively. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and potentiates senescence in vitro and in zebrafish model of hepatocellular carcinoma. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.

• Brand: Biosynth

Chemical properties

• Molecular weight: 384.43 g/mol
• Formula: C₂₀H₁₇FN₂O₃S
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
• InChI key: InChIKey=PHHZKBMVRPULAW-UHFFFAOYSA-N
• SMILES: Cc1cc(-c2ccccc2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F