HER-2 substrate peptide

Ref. 3D-CRB1000259

Product Information

• Name: HER-2 substrate peptide
• Synonyms: H-GGMEDIYFEFMGGKKK-NH2HER2 substrate
• Brand: Biosynth
• Description: Human epidermal growth factor receptor 2 (HER-2)/epidermal growth factor receptor-2 (ErbB-2), is a key receptor linked to metastasis in tumours. The oncogenic ErbB-2 receptor has intrinsic receptor tyrosine kinase (RTK) activity. The receptor is activated by ligand binding which induces receptor dimerization. These RTK complexes can activate mitogen-activated protein kinase (MAPK) and phosphoinositol 3'-kinase (PI3K)/Akt pathways. This peptide has been identified as a substrate for HER-2/ErbB-2 as it is phosphorylated upon receptor activation and therefore acts as a marker for receptor activation in kinases assays.

Chemical properties

• Molecular weight: 1,836.14 g/mol
• Purity: Min. 95%