Teduglutide (GLP2 2G)

CAS: 197922-42-2

Ref. 3D-CRB1000390

Product Information

• Name: Teduglutide (GLP2 2G)
• Synonyms: H-HGDGSFSDEMNTILDNLAARDFINWLIQTKITD-OHHGDGSFSDEMNTILDNLAARDFINWLIQTKITD-acidH-His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile- Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile -Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH
• Brand: Biosynth
• Description: Teduglutide is a GLP-2 analogue, in which the alanine at position 2 has been substituted with glycine making the peptide resistant to degradation by dipeptidyl peptidase-4 (DPP-4)- Teduglutide therefore has a longer half-life than GLP-2 (2-3 hours for teduglutide vs 7 min for GLP-2). Teduglutide has high bioavailability after subcutaneous administration, suggesting that teduglutide has enhanced biological activity, relative to native GLP-2.GLP-2 is a gut hormone produced in the enteroendocrine L cells of gastrointestinal tract by the cleavage of the 160-amino-acid proglucagon molecule. GLP-2 is secreted following the ingestion of food and carries out its activities via the GLP-2 G-protein coupled receptors (GLP-2Rs). GLP-2 has a range of roles within the cell, including: anti-inflammatory effects- promoting the expansion of the intestinal mucosa- stimulating intestinal blood flow- inhibiting gastric acid secretion and gastric emptying- increasing intestinal barrier function and enhancing nutrient and fluid absorption.

Chemical properties

• Molecular weight: 3,749.8 g/mol
• Formula: C₁₆₄H₂₅₂N₄₄O₅₅S
• Color/Form: Powder