MBMT (136-147) human
Ref. 3D-CRB1000530
1mg
254.00€
500µg
186.00€
Product Information
Name:MBMT (136-147) human
Synonyms:
- H-GNPVPILIPCHR-OH
Brand:Biosynth
Description:MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA repair enzyme that plays an important role in chemoresistance to alkylating agents. MGMT repairs the toxic DNA O6-Methylguanine lesion caused by Temozolomide (TMZ), an oral alkylating agent used for the treatment of glioblastoma. MGMT repairs damaged guanine nucleotides by transferring the methyl at O6 site of guanine to its cysteine residues, thus avoiding gene mutation, cell death and tumorigenesis. The expression of MGMT gene is mainly regulated by epigenetic modification. Loss of MGMT expression is due to methylation of the CpG island of MGMT promoter.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1,314.7 g/mol
Purity:Min. 95%
Technical inquiry about: MBMT (136-147) human
Please use instead the cart to request a quotation or an order
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.