PARP1 (487-496) peptide
Ref. 3D-CRB1000661
1mg
254.00€
500µg
186.00€
Product Information
Name:PARP1 (487-496) peptide
Synonyms:
- Ac-AEPVEVVAPR-NH2
Brand:Biosynth
Description:Amino acids 487-496 of Poly(ADP-ribose) polymerase 1 (PARP1). PARP1 is a nuclear DNA repair enzyme that binds to DNA when damage is detected. PARP1 coordinates double and single strand break repair by first cleaving NAD+ into nicotinamide and ADP-ribose, and then synthesising poly-(ADP-ribose) (PAR) chains from ADP-ribose on target proteins (PARylation). PARylation of histone proteins mediates relaxation of the chromatin and recruitment of DNA-break repair enzymes.PARP1 can also act as a transcriptional co-activator, modulating the expression of itself and many other genes by direct binding to or PARylation of enhancers and promoters. PARP1 is also involved in maintaining mtDNA.PARP1 belongs to the PARP family which has 7 known and 10 putative members. PARP1 accounts for >85% of the PARP activity in cellular systems.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1,106.6 g/mol
Purity:Min. 95%
Color/Form:Powder
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