A15

Ref. 3D-CRB1000927

Product Information

• Name: A15
• Synonyms: Ac-GNQEQVSPLTLLKWC-NH2Ac-GNQEQVSPLTLLKWC-amideAcetyl-Gly-Asn-Gln-Glu-Gln-Val-Ser-Pro-Leu-Thr-Leu-Leu-Lys-Trp-Cys-NH2ARNT-interact ing protein, Basic-
• Brand: Biosynth
• Description: A15 also known as alpha2-Antiplasmin is a serine/protease inhibitor which inactivates plasmin in the blood. To inhibit plasmin in the blood alpha2-Antiplasmin forms a protease serpin complex with plasmin due to interactions of kringle 1 or 3 of plasmin and the lysine residues of alpha2-Antiplasmin's C-terminus. Although synthesised in the Liver A15 is also present within the neurons of the human brain and its expression has been found to be enhanced in Aβ plaques of Alzheimer's disease and during myocardial infarction. A high concentration of alpha2-Antiplasmin in the blood may also contribute to an increased risk of Ischemic strokes. Alternatively its expression appears to be diminished in patients with cirrhosis and acute liver failure. A further function of A15 is its ability to regulate fibrinolysis through crosslinking to fibrin.

Chemical properties

• Molecular weight: 1,755.9 g/mol
• Purity: Min. 95%
• Color/Form: Powder