CDK7/9 tide Substrate
Ref. 3D-CRB1000935
| 1mg | 217.00 € | ||
| 500µg | 176.00 € |
Product Information
- H-YSPTSPSYSPTSPSYSPTSPSKKKK-OHcyclin dependent protein kinase 7/8/9 substrate9-tideCDK7 substrateYSPTSPSYSPTSPSYSPTSPSKKKK-acid H-Tyr-Ser-Pro-Thr-Ser-Pro-Ser-Tyr-Ser-Pro-Thr-Ser-Pro-Ser-Tyr-Ser-Pro-Thr-Ser-Pro-Ser-Lys-Lys-Lys
Cyclin-dependent kinases (CDKs) are a family of kinases that regulate the cell cycle and gene transcription. Cyclin-dependent kinase 7 (CDK7) forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK) and promotes cell cycle progression. CDK7 is an essential component of the transcription factor TFIIH, involved in DNA repair. CDK7 is also implicated in mRNA processing, transcription activation, pause induction, and pause release.CDK8 associates with the mediator complex and regulates transcription via several mechanisms, including influencing binding of RNA polymerase II to the mediator complex. CDK8 phosphorylates the Notch intracellular domain, SREBP, and STAT1. Its regulatory subunit is cyclin C. CDK9 is a component of the TAK/P-TEFb complex, which phosphorylates the part of RNA polymerase II. Its regulatory subunit is cyclin T or cyclin K. CDK9 interacts with HIV-1 Tat protein and TRAF2, and is involved in the differentiation of skeletal muscle.CDKs are often over expressed in cancers and may correlate with poor prognosis. This peptide is based on the C-terminal of RNA polymerase II and is used in kinase assays.
Chemical properties
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