SMCC-DM1

CAS: 1228105-51-8

Ref. 3D-DZB10551

Product Information

• Name: SMCC-DM1
• Brand: Biosynth
• Description: SMCC-DM1 is a cytotoxic drug conjugate component, which is a chemical compound derived from maytansine, a natural product isolated from the Ethiopian shrub *Maytenus serrata*. It primarily acts as a microtubule inhibitor by binding to tubulin, thereby disrupting the microtubule network within the cell, which results in cell cycle arrest and apoptosis.This compound is particularly valuable in the field of targeted cancer therapy. In antibody-drug conjugates (ADCs), SMCC-DM1 serves as a payload linked to a monoclonal antibody specific to a tumor antigen. Upon binding to its target antigen on the cancer cell surface, the ADC is internalized and the cytotoxic agent is released, leading to selective destruction of cancerous cells while sparing healthy tissue. This targeted approach enhances therapeutic efficacy and minimizes systemic toxicity.SMCC-DM1's robust mechanism of action and integration into ADCs make it a pivotal tool for researchers developing next-generation oncological treatments, offering significant potential in translating preclinical findings into clinical applications.

Chemical properties

• Molecular weight: 1,072.61 g/mol
• Formula: C₅₁H₆₆ClN₅O₁₆S
• Purity: Min. 95%
• Color/Form: Powder