4-Methylumbelliferyl a-D-glucosaminide

CAS: 137687-00-4

Ref. 3D-EM03198

Product Information

• Name: 4-Methylumbelliferyl a-D-glucosaminide
• Synonyms: 4-Methylumbelliferyl 2-amino-2-deoxy-a-D-glucopyranoside
• Brand: Biosynth
• Description: 4-Methylumbelliferyl alpha-D-glucosaminide is a fluorogenic substrate for alpha-N-acetylglucosaminidase. After enzymatic cleaveage, free 4-methylumbelliferone (also known as hymecromone) is released, exhibiting blue fluorescence upon excitation with UV light. The strongest fluorescence of 4-methylumbelliferone requires deprotonation of the hydroxyl group (thus requires alkaline pH), with a maximal fluorescence intensity obtained with excitation at 350 to 370 nm and emission at 440 to 470 nm. The use of 4-methylumbelliferyl alpha-D-glucosaminideas a substrate for measuring the alpha-N-acetylglucosaminidase activity is used for Sanfilippo syndrome B and Mucopolysaccharidosis IIIB (MPS IIIB) diagnosis.

Chemical properties

• Molecular weight: 337.32 g/mol
• Formula: C₁₆H₁₉NO₇
• Purity: Min. 90 Area-%
• Color/Form: White Powder