RET V804M-IN-1
CAS: 2414909-94-5
Ref. 3D-EP176311
| 5mg | 143.00 € | ||
| 10mg | 204.00 € | ||
| 25mg | 426.00 € | ||
| 50mg | 568.00 € | ||
| 100mg | 722.00 € |
Estimated delivery in United States, on Monday 27 Jan 2025
Product Information
Name:
RET V804M-IN-1
Synonyms:
- 4-[5-(3-Pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide
Description:
Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
344.37 g/mol
Formula:
C19H16N6O
Purity:
Min. 97 Area-%
Color/Form:
White Powder
InChI:
InChI=1S/C19H16N6O/c20-18(26)15-5-3-14(4-6-15)16-12-23-25-9-7-17(24-19(16)25)22-11-13-2-1-8-21-10-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)
InChI key:
InChIKey=LMGXQBQAUALFTB-UHFFFAOYSA-N
SMILES:
NC(=O)c1ccc(-c2cnn3ccc(NCc4cccnc4)nc23)cc1
MDL:
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HS code:
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