CAS 2414909-94-5

Formula: C19H16N6O

InChI: InChI=1S/C19H16N6O/c20-18(26)15-5-3-14(4-6-15)16-12-23-25-9-7-17(24-19(16)25)22-11-13-2-1-8-21-10-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)

InChI key: LMGXQBQAUALFTB-UHFFFAOYSA-N

SMILES: C1=CC(=CN=C1)CNC2=NC3=C(C=NN3C=C2)C4=CC=C(C=C4)C(=O)N

RET V804M-IN-1

CAS: 2414909-94-5

RET V804M-IN-1

Formula: C₁₉H₁₆N₆O

Purity: ≥95%

Molecular weight: 344.37

Ref: 54-BUP12576

4-(5-((Pyridin-3-Ylmethyl)Amino)Pyrazolo[1,5-A]Pyrimidin-3-Yl)Benzamide

CAS: 2414909-94-5

4-(5-((Pyridin-3-Ylmethyl)Amino)Pyrazolo[1,5-A]Pyrimidin-3-Yl)Benzamide

Formula: C₁₉H₁₆N₆O

Purity: >98%

Molecular weight: 344.37

Ref: 54-OR1024325

4-[5-(3-Pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide

CAS: 2414909-94-5

Formula: C₁₉H₁₆N₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 344.3699

Ref: IN-DA01KKND

RET V804M-IN-1

CAS: 2414909-94-5

4-(5-((Pyridin-3-ylmethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)benzamide

Formula: C₁₉H₁₆N₆O

Purity: 98+%

Molecular weight: 344.37

Ref: IN-DG01217581

RET V804M-IN-1

CAS: 2414909-94-5

RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).

Formula: C₁₉H₁₆N₆O

Purity: 97.94% - 99.62%

Color and Shape: White Solid

Molecular weight: 344.3699

Ref: TM-T8467

RET V804M-IN-1

CAS: 2414909-94-5

Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.

Formula: C₁₉H₁₆N₆O

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 344.37 g/mol

Ref: 3D-EP176311

4-(5-((PYRIDIN-3-YLMETHYL)AMINO)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE

CAS: 2414909-94-5

Purity: 98+%

Molecular weight: 344.3779907

Ref: 10-F840947