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4-5-(4-Pyridylmethylamino)pyrazolo1,5-apyrimidin-3-ylbenzamide
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4-5-(4-Pyridylmethylamino)pyrazolo1,5-apyrimidin-3-ylbenzamide

CAS: 2414373-42-3

Ref. 3D-EP176312

5mg
136.00 €
10mg
206.00 €
25mg
427.00 €
Estimated delivery in United States, on Tuesday 17 Dec 2024

Product Information

Name:
4-5-(4-Pyridylmethylamino)pyrazolo1,5-apyrimidin-3-ylbenzamide
Description:

Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
344.37 g/mol
Purity:
Min. 98 Area-%
Color/Form:
Powder
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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