Product Information
GLPG 1837 is a novel amide that modulates autophagy, an intracellular degradation process that plays a key role in the maintenance of cellular homeostasis. GLPG 1837 has been shown to inhibit autophagy in human primary cells and to protect against lipopolysaccharide (LPS)-induced lung injury. This compound also inhibits chloride conductance and produces bronchodilation in a rat model of asthma. The structural biology of this molecule has been elucidated by X-ray crystallography and NMR spectroscopy. GLPG 1837 is being developed as a potential treatment for chronic obstructive pulmonary disease (COPD).
Chemical properties
Technical inquiry about: 3D-ERC72502 GLPG 1837
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