GLPG 1837
CAS: 1654725-02-6
Ref. 3D-ERC72502
| 1mg | 180.00 € | ||
| 2mg | 259.00 € | ||
| 5mg | 365.00 € | ||
| 10mg | 487.00 € | ||
| 25mg | 774.00 € |
Product Information
GLPG 1837 is a novel amide that modulates autophagy, an intracellular degradation process that plays a key role in the maintenance of cellular homeostasis. GLPG 1837 has been shown to inhibit autophagy in human primary cells and to protect against lipopolysaccharide (LPS)-induced lung injury. This compound also inhibits chloride conductance and produces bronchodilation in a rat model of asthma. The structural biology of this molecule has been elucidated by X-ray crystallography and NMR spectroscopy. GLPG 1837 is being developed as a potential treatment for chronic obstructive pulmonary disease (COPD).
Chemical properties
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