Fludarabine triphosphate trisodium

CAS: 74832-57-8

Ref. 3D-FA103525

Product Information

• Name: Fludarabine triphosphate trisodium
• Synonyms: [(2R,3S,4S)-5-(6-Amino-2-fluoropurin-9-yl)-3,4-yihydroxyoxolan-2-Yl]methyl (hydroxy-phosphonooxyphosphoryl) ydrogen phosphate
• Brand: Biosynth
• Description: Fludarabine triphosphate trisodium is a nucleotide analog, which is a type of chemotherapy agent derived from purine nucleosides. This compound is the active metabolite of fludarabine, sourced from synthetic chemistry designed to mimic naturally occurring nucleotides involved in DNA replication. The mode of action involves its incorporation into the DNA strand during replication, where it effectively inhibits DNA polymerase and ribonucleotide reductase. This disruption impairs DNA synthesis, leading to apoptosis or programmed cell death, particularly in rapidly dividing cancer cells.

Chemical properties

• Molecular weight: 594.14 g/mol
• Formula: C₁₀H₁₅FN₅O₁₃P₃·Na₃
• Purity: Min. 95%
• Color/Form: White Powder