Aminopterin

CAS: 54-62-6

Ref. 3D-FA17838

Product Information

• Name: Aminopterin
• Synonyms: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid4-Aminofolic acid, 4-aminopteroyl-L-glutamic acid, 4-amino-PG ANSC 739, (2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid, 4-Amino-4-Deoxypteroylglutamate, 4-Amino-Folicaci, 4-Amino-Pga[Qr], 4-Aminofolic Acid, 4-Aminofolicacid[Qr], 4-Aminopteroylglutamic acid, 4-Aminopteroylglutamicacid[Qr], 4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)-N-(P-(((L-Glutamicaci, <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, Acide N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamique, Agpa, Ai3-26079[Qr], Aminopterine, Apga, Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-, Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L-, L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid, N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)glutamic acid, N-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)carbonyl]-D-glutamic acid, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsaure, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, Nsc 739, Pteramina, Pteridin-2-Amine, acido N-[4-[[(2,4-diamino-6-pteridinil)metil]amino]benzoil]-L-glutamico

Description

Aminopterin is a nitrogen mustard drug that is used as an immunosuppressant in the treatment of autoimmune diseases. It binds to Jak2, which is important for signal transduction in white blood cells, and inhibits its activity. Aminopterin also has low potency and acts on intracellular targets, such as transcriptional regulation by binding to DNA-dependent RNA polymerase and blocking the initiation of transcription.

• Brand: Biosynth

Chemical properties

• Molecular weight: 440.41 g/mol
• Formula: C₁₉H₂₀N₈O₅
• Purity: Min. 97 Area-%
• Color/Form: Slightly Yellow Powder