Product Information
Name:Dabrafenib
Synonyms:
- N-(3-(5-(2-Aminopyrimidine-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamideGSK2118436A
Brand:Biosynth
Description:Inhibitor of mutant B-rafV600E protein that results in decreased proliferation of cancer cells with this mutation. Treatment of metastatic melanoma in patients harboring the V600E mutation, had improved disease outcome. This antitumor activity is enhanced when combined with MEK inhibitor trametinib.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:519.56 g/mol
Formula:C23H20F3N5O2S2
Purity:Min. 95%
Color/Form:Powder
InChI:InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
InChI key:InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N
SMILES:CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1
Technical inquiry about: Dabrafenib
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