BOP

CAS: 56602-33-6

Ref. 3D-FB01762

Product Information

• Name: BOP
• Synonyms: Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate, (1H-benzotriazol-1-yloxy)[tris(dimethylamino)]phosphonium hexafluorophosphate, (Benzotriazol-1-yloxy)tris(dimethylamino) hexafluorophosphate, (Boranyloxy)Phosphane, 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate, 1H-Benzotriazole, 1-hydroxy-, phosphorus complex, 2-(1H-Benzotriazol-1-yl)tris(dimethylamino)phosphonium hexafluorophosphate, BOP hexafluorophosphate, BOP reagent, Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate, Castro reagent, Castro's reagent, Le BOP, Methanamine, N-methyl-, phosphorus complex, Phosphate(1-), hexafluoro-, (T-4)-(1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)phosphorus(1+), Phosphorus(1+), (1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)-, (T-4)-, hexafluorophosphate(1-), Phosphorus(1+), [1-(hydroxy-κO)-1H-benzotriazolato]tris(N-methylmethanaminato)-, (T-4)-, hexafluorophosphate(1-) (1:1)

Description

BOP, also known with the name of Castro’s reagent, is a phosphonium coupling reagent used for peptide synthesis. BOP can be employed in presence of a base such as triethylamine or Hünig’s base and forms HOBt in situ, which then generates an activated ester. BOP is a very effective coupling reagent, achieving high yields, low epimerisation and high conversion rates. However, it forms the extremely toxic and carcinogenic HMPA in situ, therefore the equally efficient pyrrolidino derivative PyBOP was introduced, which leads to a less toxic by-product.

• Brand: Biosynth

Chemical properties

• Molecular weight: 442.28 g/mol
• Formula: C₁₂H₂₂F₆N₆OP₂
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder