TDZD 8

CAS: 327036-89-5

Ref. 3D-FB18327

Product Information

• Name: TDZD 8
• Synonyms: GSK-3b inhibitor I4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione, 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-, Tdzd-8

Description

TDZD 8 is a selective, non-ATP competitive inhibitor of the glycogen synthase kinase GSK3β. TDZD 8 inhibits GSK3β with IC50 of 2 μM and was reported to not significantly affect Cdk-1/cyclin B, casein kinase CK-II, protein kinase A and C (PKA, PKC) activities. TDZD 8 was also identified as an inhibitor of the main protease in coronaviruses. In an in vitro study, TDZD 8 was characterised as an aggregate-based inhibitor as the presence of Triton-X decreased the inhibitory potency to Mpro protease of the SARS-CoV-2 virus (IC50 without Triton-X: 2.15 μM).

• Brand: Biosynth

Chemical properties

• Molecular weight: 222.26 g/mol
• Formula: C₁₀H₁₀N₂O₂S
• Purity: Min. 98 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
• InChI key: InChIKey=JDSJDASOXWCHPN-UHFFFAOYSA-N
• SMILES: Cn1sc(=O)n(Cc2ccccc2)c1=O