BIX 02188

CAS: 1094614-84-2

Ref. 3D-FB64959

Product Information

• Name: BIX 02188
• Brand: Biosynth
• Description: A selective inhibitor of MEK5 protein kinase with an IC50 value of 4.3 nM. Blocks transcriptional activation of myocyte-specific enhancer factor 2C (MEF2C). Inhibits phosphorylation of ERK5 protein kinase and thereby reverses inhibition of TNF signaling induced by fluid shear stress in endothelial cells. Induces apoptosis in FLT3-ITD cells.

Chemical properties

• Molecular weight: 412.18993
• Formula: C₂₅H₂₄N₄O₂
• Purity: Min. 95%
• InChI: InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,28,31H,15H2,1-2H3,(H2,26,30)/b27-23+
• InChI key: InChIKey=WGPXKFOFEXJMBD-SLEBQGDGSA-N
• SMILES: CN(C)Cc1cccc(/N=C(\c2ccccc2)c2c(O)[nH]c3cc(C(N)=O)ccc23)c1