Product Information
Name:BIX 02188
Brand:Biosynth
Description:A selective inhibitor of MEK5 protein kinase with an IC50 value of 4.3 nM. Blocks transcriptional activation of myocyte-specific enhancer factor 2C (MEF2C). Inhibits phosphorylation of ERK5 protein kinase and thereby reverses inhibition of TNF signaling induced by fluid shear stress in endothelial cells. Induces apoptosis in FLT3-ITD cells.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:412.18993
Formula:C25H24N4O2
Purity:Min. 95%
InChI:InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,28,31H,15H2,1-2H3,(H2,26,30)/b27-23+
InChI key:InChIKey=WGPXKFOFEXJMBD-SLEBQGDGSA-N
SMILES:CN(C)Cc1cccc(/N=C(\c2ccccc2)c2c(O)[nH]c3cc(C(N)=O)ccc23)c1
Technical inquiry about: BIX 02188
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