Product Information
- COMU4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate
- 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium
COMU is an uronium salt used as a coupling agent for peptide synthesis and phosphonamidation. COMU is safe, shows coupling effectiveness comparable to HATU, has an outstanding solubility in organic solvents such as DMF, can be conveniently used with just 1 equivalent of base, achieves great racemisation suppression and is compatible with microwave heating conditions. Additionally, its by-products are water-soluble which denotes ease of purification by extraction. A coupling reaction with COMU can be visually monitored showing colour change at its completion. The high reactivity of the dimethylmorpholino core together with the remarkable leaving group ability of the Oxyma moiety confer to COMU enhanced reactivity compared to benzotriazole-based analogues.
Chemical properties
Technical inquiry about: 3D-FC15427 COMU
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