CAS 1075198-30-9

COMU

Description:

COMU, or 1-Cyano-1-(2,4,6-trimethylphenyl)urea, is a chemical compound primarily used as a coupling reagent in peptide synthesis. It is known for its ability to facilitate the formation of amide bonds between carboxylic acids and amines, making it valuable in organic synthesis and biochemistry. COMU is characterized by its stability under various conditions, which allows for efficient coupling reactions without the need for excessive purification steps. The compound typically exhibits good solubility in organic solvents, enhancing its utility in laboratory settings. Additionally, COMU is favored for its mild reaction conditions and reduced side reactions compared to other coupling agents. Its structure includes a cyano group and a urea moiety, contributing to its reactivity and effectiveness in facilitating peptide bond formation. Overall, COMU is a significant reagent in the field of peptide chemistry, enabling the synthesis of complex peptides with high yields and purity.

Formula: C₁₂H₁₉F₆N₄O₄P

InChI: InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;

InChI key: GPDHNZNLPKYHCN-DZOOLQPHSA-N

SMILES: CCOC(=O)/C(=N\OC(=[N+](C)C)N1CCOCC1)/C#N.F[P-](F)(F)(F)(F)F

Synonyms:

• 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium

COMU

CAS: 1075198-30-9

A safe and highly efficient coupling reagent requiring only one equivalent of base during bond formation as it liberates morpholine. This helps to minimize concomitant racemization. Non-allergenic. Couplings with COMU can be monitored visually or colorimetrically, the reagent shows excellent solubility in DMF and NMP. COMU is especially suited for microwave-accelerated SPPS.

Formula: C₁₂H₁₉F₆N₄O₄P

Color and Shape: White

Molecular weight: 428.27

Ref: 01-4062545

{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosphate

CAS: 1075198-30-9

{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosphate

Formula: C₁₂H₁₉N₄O₄·PF₆

Purity: 98%

Color and Shape: Solid-Crystals

Molecular weight: 428.26784

Ref: 54-PC48468

N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate

CAS: 1075198-30-9

Formula: C₁₂H₁₉F₆N₄O₄P

Purity: 98%

Color and Shape: Solid

Molecular weight: 428.2678

Ref: IN-DA0034ML

COMU

CAS: 1075198-30-9

4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate(V)

Formula: C₁₂H₁₉F₆N₄O₄P

Purity: 98%

Molecular weight: 428.27

Ref: IN-DG220226

COMU

CAS: 1075198-30-9

COMU is an uronium salt used as a coupling agent for peptide synthesis and phosphonamidation. COMU is safe, shows coupling effectiveness comparable to HATU, has an outstanding solubility in organic solvents such as DMF, can be conveniently used with just 1 equivalent of base, achieves great racemisation suppression and is compatible with microwave heating conditions. Additionally, its by-products are water-soluble which denotes ease of purification by extraction. A coupling reaction with COMU can be visually monitored showing colour change at its completion. The high reactivity of the dimethylmorpholino core together with the remarkable leaving group ability of the Oxyma moiety confer to COMU enhanced reactivity compared to benzotriazole-based analogues.

Formula: C₁₂H₁₉F₆N₄O₄P

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 428.27 g/mol

Ref: 3D-FC15427

COMU Reagent

CAS: 1075198-30-9

COMU reagent is a copper-containing, natural compound that can be used in intrauterine diagnosis. The COMU reagent has been shown to have potent antagonistic activity against the CB2 receptor and hydrogen bond donor site. This product also can be used to detect the presence of peptide hormones, such as LH and FSH, in urine samples. The COMU reagent has been shown to bind to integrin receptors on cells, which are involved in cell adhesion and migration. The conformational properties of this compound allow it to form a complex with cyclic peptides that are found in human liver cells infected with hepatitis C virus (HCV).

Formula: C₁₂H₁₉N₄O₄F₆P

Purity: Min. 95%

Molecular weight: 428.27 g/mol

Ref: 3D-KCM-1015-PI

(1-Cyano-2-ethoxy-2-oxoethylidene aminooxy)dimethylaminomorpholino carbenium hexafluorophosphate

CAS: 1075198-30-9

Formula: C₁₂H₁₉F₆N₄O₄P

Purity: 96%

Color and Shape: Solid

Molecular weight: 428.272

Ref: 10-F044578

N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate

Controlled Product

CAS: 1075198-30-9

Applications N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate is used as an efficient coupling agent in phosphonamidation reactions; used as coupling reagent in the synthesis of solid phase peptide
References Fredriksen, K., et al.: Eur. J. Org. Chem., 3, 474 (2016); Achyuthan, K., et al.: J. Pept. Sci., 21, 751 (2015);

Formula: C₁₂H₁₉N₄O₄·F₆P

Color and Shape: Neat

Molecular weight: 428.27

Ref: TR-C797495