Cortisone acetate

CAS: 50-04-4

Ref. 3D-FC20559

Product Information

• Name: Cortisone acetate
• Synonyms: 17,21-Dihydroxypregn-4-ene-3,11,20-trione 21 acetateCortone 21-acetate21-Acetoxy-17α-hydroxy-3,11,20-triketopregnene-4, (8Alpha,9Beta,14Beta)-17-Hydroxy-3,11,20-Trioxopregn-4-En-21-Yl Acetate, (8Xi,9Xi,14Xi)-17-Hydroxy-3,11,20-Trioxopregn-4-En-21-Yl Acetate, 17,21-Dihydroxypregn-4-Ene-3,11,20-Trione, 17,21-Dihydroxypregn-4-ene-3,11,20-trione 21 acetate, 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate, 21-Acetate De Cortisone, 21-Acetato De Cortisona, 21-Acetoxy-17-hydroxypregn-4-ene-3,11,20-trione, 21-Acetoxy-17α-hydroxy-3,11,20-triketopregnene-4, 21-Acetoxy-17α-hydroxypregn-4-ene-3,11,20-trione, 4-Pregnene-17a,21-diol-3,11,20-trione 21-acetate, Adreson, Artriona, Biocort Acetate, Compound E Acetate, Corlin, Cortadren, Cortelan, Cortison-21-acetat, Cortisone 21-Acetate, Cortistab, Cortisyl, Cortisyl Artriona, Cortone acetate, Incortin, Irisone acetate, Nsc 49420, Pregn-4-Ene-3,11,20-Trione, 21-(Acetyloxy)-17-Hydroxy-, Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate, Ricortex, Scheroson

Description

Cortisone acetate is a synthetic corticosteroid with low potency. It has been used in the treatment of infectious diseases such as malaria, tuberculosis and leprosy. Cortisone acetate inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Cortisone acetate also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

• Brand: Biosynth

Chemical properties

• Molecular weight: 402.48 g/mol
• Formula: C₂₃H₃₀O₆
• Purity: 95%Min
• Color/Form: Powder