Product Information
- CyclosporinA, 11-L-leucine-
- 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane,cyclic peptide deriv.
- Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-L-leucyl]
Cyclosporine U is a cytostatic drug that is used to treat various types of cancers, including leukemia and lymphoma. It is also used to prevent rejection of transplanted organs. Cyclosporine U is available as a prescription drug and can be administered orally. The preparation of cyclosporine U involves the following steps: (1) the removal of l-norvaline from cyclosporine A; (2) the conversion of the resulting cyclosporine A to an ester with hplc analysis; and (3) the conversion of this ester to cyclosporine U by conjugation with phosphate derivatives. Cyclosporine U is not active against viruses or bacteria but has been shown to suppress the immune system by preventing T-cell activation and proliferation. Cyclosporine U binds specifically to T-lymphocytes, which are responsible for cell-mediated immunity, and prevents their activation. This binding inhibits production of interleuk
Chemical properties
Technical inquiry about: 3D-FC35377 Cyclosporine U
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