(+)-JQ 1

CAS: 1268524-70-4

Ref. 3D-FC43273

Product Information

• Name: (+)-JQ 1
• Synonyms: [(S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester(S)-(
• Brand: Biosynth
• Description: Potent BET inhibitor with high specificity for acetyl-lysine recognition motifs found in the BET family (Brd2, Brd3, Brd4, Brdt). Engages with bromodomain pocket and competes with acetylated peptide binding, causing displacement of BET proteins from chromatin and disrupting transcription. Has been used in clinical trials as chemotherapy and male contraceptive.

Chemical properties

• Molecular weight: 456.99 g/mol
• Formula: C₂₃H₂₅ClN₄O₂S
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
• InChI key: InChIKey=DNVXATUJJDPFDM-KRWDZBQOSA-N
• SMILES: Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2